HegeLab.org

Theses
Talks
Posters

Papers

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  1. Veit, G., Avramescu, R.G., Perdomo, D., Phuan, P.W., Bagdany, M., Apaja, P.M., Borot, F., Szöllősi, D., Wu, Y.S., Finkbeiner, W.E., Hegedus, T., Verkman, A.S., Lukacs, G.L., Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression. Sci Transl Med. 2014 Jul 23;6(246):246 PubMed: 25101887
  2. Szöllősi, D., Horváth, T., Han, KH, Dokholyan, N.V., Tompa, P., Kalmár, L., Hegedűs, T., Discrete molecular dynamics can predict helical prestructured motifs in disordered proteins. PLOS ONE 2014 (accepted for publication)
  3. Sarankó, H., Tordai, H., Telbisz, Á., Özvegy-Laczka, C., Erdős, G., Sarkadi, B., Hegedűs, T., Effects of the gout-causing Q141K polymorphism and a CFTR ΔF508 mimicking mutation on the processing and stability of the ABCG2 protein. Biochem Biophys Res Commun. 2013, 19:140-5. PubMed: 23800412
  4. Okiyoneda, T., Veit, G., Dekkers, J.F., Bagdany, M., Soya, N., Xu, H., Roldan, A., Verkman, A.S., Kurth, M., Simon, A., Hegedus, T., Beekman, J.M., Lukacs, G.L., Mechanism-based corrector combination restores ΔF508-CFTR folding and function. Nature Chemical Biology 2013, 9:444-54. DOI:10.1038/NChemBio.1253
  5. Telbisz, A., Ozvegy-Laczka, C., Hegedűs, T., Varadi, A., Sarkadi, B., Effects of the lipid environment, cholesterol and bile acids on the function of purified, reconstituted human ABCG2 protein. Biochem J. 2013, 450:387-95. PubMed: 23205634
  6. Hegedűs, T., Gyimesi, G., Gáspár, M.E., Szalay, K.Z., Gangal, R., Csermely, P., Potential application of network descriptions for understanding conformational changes and protonation states of ABC transporters. Curr Pharm Des. 2013, 19:4155-72. PubMed: 23170883
  7. Gyimesi, G., Borsodi, D., Sarankó, H., Tordai, H., Sarkadi, B., Hegedűs, T., ABCMdb: a database for comparative analysis of mutations in ABC transporters, and potential framework for a general application, Human Mutation 2012, 33(11):1547-56. PubMed:22693078
  8. Gyimesi, G., Ramachandran, S., Kota, P., Dokholyan, N.V., Sarkadi, B., Hegedűs, T., ATP hydrolysis at one of the two sites in ABC transporters initiates transport related conformational transitions. BBA Biomembranes 2011, 1808(12):2954-64. PubMed: 21840296;
  9. Brózik, A., Hegedűs, C., Erdei, Z., Hegedűs, T., Özvegy-Laczka, C., Szakács, G., Sarkadi, B., Tyrosine kinase inhibitors as modulators of ATP binding cassette multidrug transporters: substrates, chemosensitizers or inducers of acquired multidrug resistance? Expert Opin Drug Metab Toxicol. 2011, 7:623-42. PubMed: 21410427.

Theses

  1. Borsodi, D., A mutational database and web application for studying ABC proteins (M.Sc. thesis in English), Budapest University of Technology and Economics, Faculty of Biomedical Engineering, Budapest, 2011. Thesis (English);
  2. Gyimesi, G., Information entropy in characterizing conformational ensembles and intrinsic dynamics of polypeptides (Ph.D. thesis in Hungarian), Péter Pázmány Catholic University, Budapest, 2011. Thesis (Hungarian), Thesis booklet (Hungarian), Thesis booklet (English).

Talks

  1. Hegedűs, T., Conformation, dynamics, and transport mechanism of ABC proteins, 41st Membrane Transport Conference, Sümeg, Hungary, May of 2011;
  2. Hegedűs, T., Role of ABC proteins in cystic fibrosis and Alzheimer's disease, Gedeon Richter Plc, Budapest, Hungary, June of 2011;
  3. Hegedűs, T., Telbisz, A., Sarkadi, B, Purification of functional ABC transporters for structural studies, Locher-Lab, ETH, Zurich, Switzerland, March, 2011;
  4. Hegedűs, T., The role of F508 in the domain folding and in the domain-domain assembly of CFTR, Department of Biophysics, University of Debrecen, Debrecen, Hungary, November, 2010;
  5. Hegedűs, T., Structure and dynamics of ABC proteins: interplay of computation and Experiments, Department of Biochemistry, University of Oxford, Oxford, UK, October, 2010;
  6. Gyimesi, G., Ramachandran, S., Kota, P., Dokholyan, N.V., Sarkadi B., Hegedűs, T., Computational Study of the Long Scale Dynamics of ABC Proteins. 7th North American ABC meeting, NCI-Frederick, Frederick, MD, USA, September, 2010;
  7. Tordai, H., Özvegy-Laczka, C., Tusnády, E.G., Aleksandrov, L., Riordan, J.R., Sarkadi, B., Hegedűs T., Investigation of membrane topology of ABC proteins using computational and experimental methods, Membrane Transport Conference, Sümeg, Hungary, May of 2010 (oral presentation selected from posters).

Posters

  1. Gyimesi, G., Borsodi, D., Tordai, H., Sarankó, H., Sarkadi, B., Hegedűs, T., Harvesting ABC protein mutations from the literature: automated extraction pipeline, database, and web framework for homology-based mutagenetic studies, 4th FEBS Special Meeting: ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases, Innsbruck, Austria, March of 2012 (selected for ABC2012 Young Investigator Award);
  2. Sarankó, H., Tordai, H., Sarkadi, B., Hegedűs, T.,
    Structural studies of the NBD and the linker region of ABCG2, 4th FEBS Special Meeting: ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases, Innsbruck, Austria, March of 2012;
  3. Gyimesi, G., Borsodi, D., Sarkadi, B., Hegedűs, T., A database with mutagenetic data extracted from the literature for comparative analysis of mutations in ABC proteins, SFB35 - Transmembrane Transporters in Health and Disease, Vienna, Austria, September of 2011;
  4. Tordai, H., Sarankó, H., Gyimesi, G., Borsodi, D., Sarkadi, B., Hegedűs, T., A database with mutagenetic data extracted from the literature for comparative analysis of mutations in ABC proteins, 8th Annual North American ABC Meeting, NCI-Frederick, Frederick, MD, USA, September of 2011;
  5. Gyimesi, G., Ramachandran, S., Kota, P., Dokholyan, N.V., Sarkadi, B., Hegedűs, T., ATP hydrolysis at one of the two sites in ABC transporters initiates transport related conformational transitions, 4th European Conference on Chemistry for Life Sciences (4ECCLS), Budapest, Hungary, September of 2011;
  6. Tordai, H., Özvegy-Laczka, C., Tusnády, E.G., Aleksandrov, L., Riordan, J.R., Sarkadi, B, Hegedűs, T., Investigation of membrane topology of ABC proteins using computational and experimental methods, Membrane Transport Conference, Sümeg, Hungary, May of 2010;
  7. Gyimesi, G., Ramachandran, S., Kota, P., Dokholyan, N.V., Sarkadi, B., Hegedűs, T., Characterizing the dynamics of different conformers of ABC transporters. Membrane Transport Conference, Sümeg, Hungary, May of 2010;
  8. Gyimesi, G., Ramachandran, S., Kota, P., Dokholyan, N.V., Sarkadi, B., Hegedűs, T., Characterizing the dynamics of different conformers of ABC transporters. ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Disease, Innsbruck, Austria, 2010 (in the 15 best posters out of ~200).